মঙ্গলবার, ৩১ জানুয়ারী, ২০১২

Democrats slam Tea Party ties in Oregon special election (Reuters)

(Reuters) ? An Oregon special election in which national Democrats have sought to paint the Republican congressional candidate as a Tea Party radical foreshadows a tactic the party will employ in its quest to take back Congress seats lost in the 2010 election.

The Democratic Congressional Campaign Committee has spent about $1.3 million in the race, half of it opposing Republican businessman Rob Cornilles in Tuesday's election to replace Democratic ex-Representative David Wu.

Television advertising and a website run by the committee, which supports Democrats in House of Representatives races, slam Cornilles for referring to himself as "the original Tea Party candidate" during a previous congressional run.

The race between Cornilles and Democratic state Senator Suzanne Bonamici is a preview of an already heated election year when outside groups are pumping money into opposition advertising, and Democrats plan to attack conservatives who have curried favor with the Tea Party.

"There is no doubt that races across the country will be about a contrast between Tea Party extremism that protects the ultra-wealthy versus defenders of the middle class and Medicare," said Jesse Ferguson, a spokesman for DCCC.

"But in each district, the message will fit the district, the local values of the community and the candidates running."

The race has attracted an unusual level of interest for a traditionally safe Democratic seat. Obama easily won the Portland-area district in 2008, and Wu beat Cornilles in a 2010 election year that heavily favored Republicans elsewhere in the country.

Wu, who was in his seventh term, in July announced he would resign after a sex scandal. The race to replace him will wrap up on Tuesday, when Oregon's vote-by-mail ballots are due.

The election has drawn almost $2 million in independent expenditures since November despite the fact that early polling showed Bonamici, a former Federal Trade Commission lawyer who has served in the Oregon Senate since 2008, with a considerable lead.

CYBER ATTACKS

Democrats have made Cornilles' Tea Party statement, made at a May 2010 event, a central part of their attack on the Republican, who runs a sports-consulting business.

Teapartycornilles.com, a website paid for by the DCCC, features the quote, raps Cornilles for his "extreme" opposition to abortion and claims he supports ending tax cuts for middle-class families.

A fake Twitter account, @TPartyCornilles, sends out comments such as, "Will Republican Rob Cornilles try to run from his extreme Tea Party anti-choice record in tonight's debate?"

Many Republican candidates attended Tea Party events and sought endorsements from local chapters in 2010 to fend off primary challenges or third-party candidates as support for the Tea Party's small-government mantra swelled.

But public sentiment has since shifted, with Tea Party-sanctioned Republican freshmen in the House of Representatives taking much of the blame for standoffs over the extending debt ceiling, extending payroll taxes and other issues in 2011.

Oregon Republicans say all the Democratic-aligned money is proof Democrats are worried about losing more seats in 2012. Cornilles' campaign recently released an internal poll showing him within four points of Bonamici.

"I think the DCCC has kind of hit the panic button here...the more they've spent, the closer the numbers have gotten," said Greg Leo, chief of staff for the Oregon Republican Party.

"I don't think it's really an accurate referendum on the Tea Party, nor is it an accurate description of Rob Cornilles," Leo said, pointing to the candidate's refusal to sign Grover Norquist's no-tax pledge as evidence Cornilles is not driven by the Tea Party.

The multi-media approach to attacking Tea Party-aligned candidates could be employed in other districts leading up to the November general election when all House seats and a third of the Senate are up for re-election.

"If somebody comes out as a Tea Partier, we're going there," said Trent Lutz, executive director of the Oregon Democratic Party. "If they drape themselves in the Tea Party banner, then absolutely it's something that we will discuss."

Democrats also have run sharp ads in Oregon claiming Cornilles has overstated the number of jobs created by his consulting business. A coalition of women's groups paid for ads and mailers criticizing the Republican for his pro-life views.

The National Republican Congressional Committee pitched in on a coordinated ad buy with the Cornilles campaign, but nearly all of the outside spending reported in the race came from Democratic groups.

Republican ads say Bonamici lacks experience creating private sector jobs and that she has voted to raise taxes while in the state Senate. One Cornilles ad tries to hurt her image by linking her to Wu, also a Democrat.

(Reporting By Emily Stephenson, additional reporting by Alexander Cohen; Editing by Cynthia Osterman)

Source: http://us.rd.yahoo.com/dailynews/rss/uscongress/*http%3A//news.yahoo.com/s/nm/20120130/ts_nm/us_usa_campaign_oregon

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iaffe-europe.org: Tips For Navigating The Auto Insurance Lanscape

Auto insurance is vital for all drivers. It may be rather difficult to find the appropriate automobile insurance arrange when there are actually so several insurance businesses to pick from. Read on for some tips about discovering auto insurance that fits your requirements and also your budget.

Maintaining a driving record that is fully clean up is the top piece of advice about automobile insurance you will receive. Receiving within a cat accident will result in your premiums to grow right away. Be mindful of your limitations if you drive, and steer clear of instances can lead to accidents. When you have a difficult time seeing at night, you shouldn?t drive during this time.

Explore the reputation of any company just before you get associated with them. It?s essential to get insurance you may afford, but that?s not the only essential consideration. It is not uncommon for your cheapest insurance plans to skimp on elements like buyer support, cooperation, and compensation for claims.

Many insurance businesses give special discounts for your elderly. It may be nice to find a possible 10% discount on your insurance policy.

To begin saving funds right away, raise your deductibles. This move has some risk, but is could save you some dollars. When you do it, put the additional funds within a cost savings account so you do have it, need to you ever need to cope with the deductible. The higher you set the deductible, the lower your insurance premiums will be.

Many state laws enable insurance businesses a grace period for them to end your policy with out offering you a reason. When you take a stable driving and monetary history, this is unlikely, but keep your explore into other carriers convenient in case you have to buy one more policy.

You will wish to eliminate any driver from your auto insurance policy who no more drives your vehicle. You need to take the additional driver off of, as you are most likely paying more to enjoy them covered.

Various aspects figure out the insurance costs you get quoted. As an example marriage, your gender and even your age are aspects. When you know these aspects, and how they have an impact on your coverage costs, you may be more aware of what costs are suitable when cost shopping.

Going using a larger deductible is one straightforward strategy to cut your automobile insurance costs. Insurance businesses will commonly give you a speed reduction if you take a larger deductible. This really is as you are not as likely to put within a claim for something that only causes a few hundred dollars? worthy of of damage. Yet you need to be conscious of that having a higher deductible means you need to pay more in case you do file a claim.

Automobile insurance costs can in fact change in accordance with place. A geographical element that determines the expense of your insurance is crime speed.

Once you?ve sold a car or truck, or no more have it in the possession, be sure to let your insurance carrier know immediately, so that it may be taken out of your policy. Carrying insurance you don?t need to have can cost you cash, so make sure you handle this fairly quickly.

Having the appropriate form of insurance can save an individual quite a bit of dollars if they get into some form of accident. The company possesses the buyer pay a predetermined amount, recognized as a deductible, and any costs above that amount are covered by the insurers.

Do not risk driving with out auto insurance! Having insurance will prevent you from becoming the reason for a massive monetary setback in case you are ever in an accident. The ideas you?ve read through in this post will guide you when you seek out the most effective insurance arrange for the needs.

Rent-A-Wreck at Monarch Auto Sales, conveniently located on West Market Street between Holden & Pomona, offers a wide selection of vehicles for a great rate. FREE pick-up & return service, low rates, AAA discount available, Car Rental Under 25 drivers welcome, cash/check card/credit card rentals welcome.

Source: http://www.iaffe-europe.org/tips-for-navigating-the-auto-insurance-lanscape/

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সোমবার, ৩০ জানুয়ারী, ২০১২

FASEB SRC announces conference registration open for: Tyrosine Kinase Signaling in Cancer, Disease, and Development

FASEB SRC announces conference registration open for: Tyrosine Kinase Signaling in Cancer, Disease, and Development [ Back to EurekAlert! ] Public release date: 30-Jan-2012
[ | E-mail | Share Share ]

Contact: Jessica Lyons
SRC@faseb.org
301-634-7010
Federation of American Societies for Experimental Biology

Bethesda, MD The Federation of American Societies for Experimental Biology (FASEB) announces the opening of registration for the Science Research Conference (SRC): Tyrosine Kinase Signaling in Cancer, Disease, & Development.

This conference will take place in Snowmass, Colorado on July 22-27, 2012. Attendees will learn about the latest research on dissecting the signaling pathways regulated by soluble and membrane receptor tyrosine kinases. Highlights include the analysis of crosstalk and complex signaling networks, the use of mass spectrometry, role of miRNA in pathway regulation, and involvement of tyrosine kinases and their downstream targets in growth, adhesion, invasion, metastasis, the tumor microenvironment, angiogenesis, immunology, and neurobiology. To foster collaboration and translational research, presentations and a special workshop on therapeutic targeting will be hosted by experts. Travel grants and poster awards will be available for trainees. An impressive slate of world-renown speakers combined with the intimacy of a highly focused agenda with ample opportunities for discussion and interaction, are designed to enhance collaboration and foster new ideas and research directions in the field.

###

Since 1982, FASEB SRC has offered a continuing series of inter-disciplinary exchanges that are recognized as a valuable complement to the highly successful society meetings. Divided into small groups, scientists from around the world meet intimately and without distractions to explore new approaches to those research areas undergoing rapid scientific changes.

In recent years, the SRC series has expanded into non-summer months. To better enhance the SRC series and allow for future expansion of conferences, FASEB's Office of Scientific Meetings and Conferences recently changed the SRC name from Summer Research Conferences to Science Research Conferences.

FASEB SRC has announced a total of 36 SRCs in 2012, spanning from June through October. To register for an SRC, view preliminary programs, or find a listing of all our 2012 SRCs, please visit http://www.faseb.org/SRC.

Additionally, in efforts to continue expanding the SRC series, potential organizers are encouraged to contact SRC staff at SRC@faseb.org. Proposal guidelines can be found by clicking "Submit a Proposal" on our website at http://www.faseb.org/SRC.

FASEB is composed of 26 societies with more than 100,000 members, making it the largest coalition of biomedical research associations in the United States. Celebrating 100 Years of Advancing the Life Sciences in 2012, FASEB is rededicating its efforts to advance health and well-being by promoting progress and education in biological and biomedical sciences through service to our member societies and collaborative advocacy.



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


FASEB SRC announces conference registration open for: Tyrosine Kinase Signaling in Cancer, Disease, and Development [ Back to EurekAlert! ] Public release date: 30-Jan-2012
[ | E-mail | Share Share ]

Contact: Jessica Lyons
SRC@faseb.org
301-634-7010
Federation of American Societies for Experimental Biology

Bethesda, MD The Federation of American Societies for Experimental Biology (FASEB) announces the opening of registration for the Science Research Conference (SRC): Tyrosine Kinase Signaling in Cancer, Disease, & Development.

This conference will take place in Snowmass, Colorado on July 22-27, 2012. Attendees will learn about the latest research on dissecting the signaling pathways regulated by soluble and membrane receptor tyrosine kinases. Highlights include the analysis of crosstalk and complex signaling networks, the use of mass spectrometry, role of miRNA in pathway regulation, and involvement of tyrosine kinases and their downstream targets in growth, adhesion, invasion, metastasis, the tumor microenvironment, angiogenesis, immunology, and neurobiology. To foster collaboration and translational research, presentations and a special workshop on therapeutic targeting will be hosted by experts. Travel grants and poster awards will be available for trainees. An impressive slate of world-renown speakers combined with the intimacy of a highly focused agenda with ample opportunities for discussion and interaction, are designed to enhance collaboration and foster new ideas and research directions in the field.

###

Since 1982, FASEB SRC has offered a continuing series of inter-disciplinary exchanges that are recognized as a valuable complement to the highly successful society meetings. Divided into small groups, scientists from around the world meet intimately and without distractions to explore new approaches to those research areas undergoing rapid scientific changes.

In recent years, the SRC series has expanded into non-summer months. To better enhance the SRC series and allow for future expansion of conferences, FASEB's Office of Scientific Meetings and Conferences recently changed the SRC name from Summer Research Conferences to Science Research Conferences.

FASEB SRC has announced a total of 36 SRCs in 2012, spanning from June through October. To register for an SRC, view preliminary programs, or find a listing of all our 2012 SRCs, please visit http://www.faseb.org/SRC.

Additionally, in efforts to continue expanding the SRC series, potential organizers are encouraged to contact SRC staff at SRC@faseb.org. Proposal guidelines can be found by clicking "Submit a Proposal" on our website at http://www.faseb.org/SRC.

FASEB is composed of 26 societies with more than 100,000 members, making it the largest coalition of biomedical research associations in the United States. Celebrating 100 Years of Advancing the Life Sciences in 2012, FASEB is rededicating its efforts to advance health and well-being by promoting progress and education in biological and biomedical sciences through service to our member societies and collaborative advocacy.



[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2012-01/foas-fsa_8013012.php

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Obama pokes fun during dinner for capital elites (AP)

WASHINGTON ? President Barack Obama told some jokes and poked a little fun at himself as he addressed the Alfalfa Club dinner, an exclusive annual black-tie get-together of some of the capital's movers and shakers.

The club's sole mission is to put on a steak-and-lobster feast while giving high-powered politicians and business leaders another opportunity to rub elbows and share some laughs. Saturday night's dinner was, as in years past, off limits to reporters.

"It is great to be here tonight, because I have about 45 more minutes on the State of the Union that I'd like to deliver tonight," the president told the gathering, according to excerpts released by the White House.

Among those attending were current and former senators, including John Kerry of Massachusetts and Pat Leahy of Vermont. Former President George H.W. Bush and his son Jeb, a former governor of Florida, were also on the guest list.

"You've heard it from the pundits: `Obama is cloistered in the White House.' `He's aloof.' `He's in the bubble.' `He's not connecting,'" the president said. "And that's why one of my big goals this year was to get out and be among everyday, ordinary Americans -- like the men and women of the Alfalfa Club."

His appearance at the dinner came at the end of a high profile week for the president, beginning with his address to a joint session of Congress and ending with a three-day tour of five states that included an exchange of words with Arizona Gov. Jan Brewer.

According to club history, the club is named after the alfalfa because the plant extends its roots far for a drink.

Obama was joined at the dinner, at a hotel near the White House, by his wife, Michelle.

It was the second club dinner the president addressed in four years. He last spoke at the dinner in 2009 but skipped the soiree last year and in 2010.

Source: http://us.rd.yahoo.com/dailynews/rss/us/*http%3A//news.yahoo.com/s/ap/20120129/ap_on_go_pr_wh/us_obama_alfalfa

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রবিবার, ২৯ জানুয়ারী, ২০১২

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Stanley builds 5-shot lead at Torrey Pines

Kyle Stanley tees off on the seventh hole of the South Course at Torrey Pines during the third round of the Farmers Insurance Open golf tournament Saturday, Jan. 28, 2012 in San Diego. (AP Photo/Chris Carlson)

Kyle Stanley tees off on the seventh hole of the South Course at Torrey Pines during the third round of the Farmers Insurance Open golf tournament Saturday, Jan. 28, 2012 in San Diego. (AP Photo/Chris Carlson)

Kyle Stanley hits tee shot on the third hole during third round of the Farmers Insurance Open Golf tournament in San Diego, Saturday, Jan. 28, 2012. (AP Photo/Chris Carlson)

Kyle Stanley waves after his first putt on the third hole during third round of the Farmers Insurance Open Golf tournament in San Diego,use thi

John Huh watches his chip on the sixth hole of the South Course at Torrey Pines during the third round of the Farmers Insurance Open golf tournament Saturday, Jan. 28, 2012 in San Diego. (AP Photo/Lenny Ignelzi )

John Huh watches his approach shot to the second green of the South Course at Torrey Pines during the third round of the Farmers Insurance Open golf tournament Saturday, Jan. 28, 2012 in San Diego. (AP Photo/Lenny Ignelzi )

(AP) ? Hang gliders were taking off from the cliffs behind the 13th tee at Torrey Pines where Kyle Stanley was waiting to tee off on the 524-yard hole. Then, the 24-year-old launched a shot that was just as majestic.

"Wait 'til to you see where this one went," caddie Brett Waldman said.

On another clear day along the Pacific coast, it was hard not to notice.

In a familiar performance ? even if the name might not be all that familiar now ? Stanley overpowered the South Course on Saturday on his way to a 4-under 68 that gave him a five-shot lead going into the final round at the Farmers Insurance Open.

"For some reason, I've always been long," said Stanley, who has a slight but athletic build and generates enormous speed. "But if you take a golf course like this where you're hitting 7-irons into par 5s and short irons into long par 4s, it definitely helps."

It never hurt Tiger Woods, a seven-time winner as a pro at Torrey Pines.

Stanley chose to lay up on the par-5 18th with the large pond in front, and spun a wedge near the hole to about 4 feet. About his only regret in the third round was missing that putt. One last birdie would have broken the 54-hole tournament record that Woods set in 1998, before Rees Jones beefed up the South Course to 7,698 yards for the 2008 U.S. Open.

Stanley grew up outside Seattle when Woods ruled the sport. All through his school, he kept a poster of Woods over his bed.

"I think he's definitely influenced me, and a lot of other people, too," Stanley said.

He gladly settled for a spot alongside Woods in the record book at 18-under 198, and a five-shot lead over John Huh and John Rollins as he goes after his first PGA Tour title.

Stanley can't recall ever having a lead this large, which can be troublesome if looked upon as only an opportunity to fail.

"I think the biggest thing is you can't necessarily go out there and try to protect it," Stanley said. "You've got to really just keep doing what got you to this point. I'm not going to be any more conservative tomorrow. I'll stick to my game plan off the tee, and hopefully just continue to give myself a lot of chances."

He hit driver on all but three holes, and four of them traveled at least 320 yards, a big number considering Torrey Pines is just a cliff over sea level and even in pleasant weather, the ball doesn't go quite as far as summer in Ohio.

Big numbers are nothing new for Stanley, however.

He recalls coming down to the Titleist Performance Institute when he was a 17-year-old in his senior year in high school. His ball speed was measured at 184 mph.

"Now, I can't get it above 176," he said.

It wasn't just the big drives. Stanley showed exquisite control of his irons, especially his distance, and he has been working overtime the last few years on dialing in his wedges from inside 120 yards.

Even so, he refused to look ahead to Sunday and what a win might mean ? a trip to the Masters, perhaps a spot in the World Golf Championships, a two-year exemption.

No one was giving him the trophy, either.

"If a guy had a 10- or 12-shot lead, you'd feel pretty comfortable," Rollins said after his 68. "But when you're four or five shots, sometimes it's hard to play with a big lead because you get kind of relaxed and everything else."

Rollins should know. He had a three-shot lead with five holes to play in 2009, losing to Nick Watney.

Still, Stanley, the former All-American from Clemson aspires to play boring golf and not look too far ahead.

His lone bogey came on the 12th, when he went just over the green, chipped to 6 feet and missed the putt. Then came the big blast on the 13th ? "As good as I can possibly hit it," he said ? that left him a soft 7-iron to 15 feet on the fringe below the hole for an easy birdie.

"Are you playing this as a par 4?" Sang-Moon Bae turned and said to him with a smile.

Huh, a 21-year-old rookie who spent three years on the Korean Tour, also had a 68 and joined Rollins at 13-under 203. FedEx Cup champion Bill Haas (70) and Bae (72) were another shot behind. Bae was 5 over through five holes until he ran off four straight birdies to start the back nine to get his name back on the leaderboard.

The question is whether anyone else is in contention.

Stanley is no surprise to those who play with him or watch him hit balls, and he nearly joined the parade of rookie winners last year until Steve Stricker rallied with birdies on the last two holes to beat him in the John Deere Classic.

Stanley had a one-shot lead over Brandt Snedeker going into the third round at Torrey Pines, and before long had a comfortable lead, just as Woods has done on this public course.

From deep rough on the par-5 sixth, Stanley hammered a shot just short of the green and pitched up to 12 feet for birdie. He hit sand wedge to 10 feet on the 10th for another birdie, then established himself on the back nine.

Along with the easy birdie on the 13th, Stanley saved par on the 14th. The day before, his approach jumped out of the rough and over the green for a double bogey. Playing it safe this time, he hit 9-iron that went well short, into the bunker, but blasted out to 8 feet and made a tricky, downhill putt for par.

His final birdie came on a 20-foot putt at the par-3 16th. No one else could make a move.

Snedeker went to tap in a 2-foot par putt on the seventh and was shocked when it made a horseshoe around the cup. He then missed his next five greens in regulation, and when he got home in two on the 13th, he three-putted. Snedeker had a 74 and fell seven behind.

"This is something you dream about as a kid," Stanley said. "But there's still one more round."

DIVOTS: Jay Don Blake in 1991 was the last player to make Torrey Pines his first PGA Tour victory. ... Ryo Ishikawa had his third consecutive round of 69 and was tied for 11th. ... Jonas Blixt had the low round Saturday at 65. Under a "University of Farmers" campaign, that was worth a $20,000 donation to his alma mater, Florida State. Cameron Tringale (Georgia Tech) had a 66 to finish second, which was worth $10,000.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2012-01-28-Farmers%20Insurance/id-35a316679c114b148c08a3d8c2ad5963

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শনিবার, ২৮ জানুয়ারী, ২০১২

Economy picked up pace as 2011 ended

Paul Sakuma / AP

Chevy Malibus are shown at a car dealership in San Jose, Calif. An increase in consumer spending, which accounts for about 70 percent of U.S. economic activity, was largely driven by pent-up demand for motor vehicles in the fourth quarter.

By msnbc.com staff and wire

U.S. economic growth picked up speed in the final three months of 2011, expanding at the fastest pace in 1-1/2 years, according to new data released Friday.

The latest U.S. gross domestic product data show the economy expanded at a 2.8 percent annual rate in the October-December quarter, the Commerce Department said -- a sharp acceleration from the 1.8 percent clip of the prior three months and the quickest pace since the second quarter of 2010.

It was, however, a touch below economists? expectations for a 3.0 percent rate. Also,?businesses aggressively restocking their shelves and weak spending on capital goods hinted at slower growth in early 2012.

?The economy ended 2011 on a fairly positive note, but the composition of growth in the last quarter is not favorable for growth early this year,? said Ryan Sweet, a senior economist at Moody's Analytics in West Chester, Pennsylvania.

Sweet made the comments before the report was released. For the whole of 2011, the economy grew 1.7 percent after expanding 3 percent the prior year.

Growth in the fourth quarter got a temporary boost from the rebuilding of business inventories, which was the fastest since the third quarter of 2010, after they declined in the third-quarter for the first time since late 2009.

Inventories increased $56.0 billion, adding 1.94 percentage points to GDP growth. Excluding inventories, the economy grew at a tepid 0.8 percent rate, a sharp step-down from the prior period's 3.2 percent pace.

The robust stock accumulation suggests the recovery will lose a step in early 2012.

Also pointing to slower growth, business spending on capital goods was the slowest since 2009, a sign the debt crisis in Europe was starting to take its toll.

Vote: Will the economy continue to accelerate?

Expectations of soft growth led the Federal Reserve on Wednesday to say it expected to keep interest rates at rock bottom levels at least through late 2014.

Fed Chairman Ben Bernanke said the central bank, which forecast growth this year in a 2.2 percent to 2.7 percent range, was mulling further asset purchases to speed up the recovery.

The Fed warned the economy still faced big risks, a suggestion the euro zone debt crisis could still hit hard.

?The Fed is attempting to shield the economy from a potentially more severe recession in Europe,? said Sweet. ?Even though the economy improved last quarter there are a number of headwinds and a lot of uncertainty surrounding Europe, emerging markets and also U.S. fiscal policy.?

Treasury Secretary Timothy Geithner told the World Economic Forum in Davos the U.S. economy still faced big challenges.

?We're still repairing the damage done by the financial crisis. On top of that we face a more challenging world. We have a lot of challenges ahead in the United States,? Geithner said.

Consumer spending, which accounts for about 70 percent of U.S. economic activity, stepped to a 2 percent rate from the third-quarter's 1.7 percent pace -- largely driven by pent-up demand for motor vehicles.

The Japanese earthquake and tsunami had disrupted supplies early in the year, leaving showrooms bereft of popular models.
Spending was also lifted by moderate inflation.

A price index for personal spending rose at a 0.7 percent rate in the fourth-quarter, the slowest increase in 1-1/2 years, after rising at a 2.3 percent pace in the July-September period.

A core inflation measure, which strips out food and energy costs, increased at a 1.1 percent rate after rising 2.1 percent in the third quarter.

The increase last quarter was the smallest in a year and put this measure well below the Fed's 2 percent target.

Reuters contributed to this report.

Source: http://bottomline.msnbc.msn.com/_news/2012/01/27/10249993-economy-ended-2011-at-a-healthy-pace

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Greece tries to revive debt relief deal (AP)

ATHENS, Greece ? Greece will try to revive a debt relief deal needed to avoid a potentially disastrous default when it resumes talks on Thursday with its private creditors in Athens.

Greek Premier Lucas Papademos will meet with Charles Dallara, managing director of the Institute of International Finance, a banking lobby, and Jean Lemierre, senior adviser to the chairman of French bank BNP Paribas.

The euro100 billion ($129 billion) private debt writedown is a vital condition of a new bailout for Greece, which has been relying on international rescue loans since May 2010.

The recession-plagued country is at the heart of Europe's debt crisis, and fears that it could become the first of the 17 euro states to default have roiled global markets over the past two years.

If the writedown fails, Greece will be unable to repay a euro14.5 billion ($18.77 billion) bond on March 20. If that happened, it could then be forced to leave the euro, which would be disastrous for the country and destabilize the rest of the region.

Under the deal, banks and other private sector investors would swap their Greek government bonds for new ones with half the face value, longer repayment deadlines and potentially lower interest rates.

Following intensive talks in Athens last week, Dallara said private bondholders had made the "maximum" offer that would ensure the bond swap is voluntary, as initially intended, warning that the alternative was a Greek default. But eurozone finance ministers later increased the stakes, urging bondholders to accept a lower interest rate ? well below 4 percent on average ? on the new bonds.

The IIF said in a statement that the goal of the talks is to agree on all outstanding legal and technical issues as soon as possible.

Papademos' interim coalition government is hoping to conclude the negotiations by the end of this week, despite disagreements over the terms of the deal, which is intended to make Greece's borrowings sustainable in the long term by lowering the debt burden to 120 percent of GDP by 2020 from 160 percent in 2011.

"We hope the process ends quickly and we are able to implement the agreement, because the (writedown) must take place and the (new international bailout) must be signed if we want to keep financing the economy," government spokesman Pantelis Kapsis said.

"Developments could potentially be very rapid, and a series of issues could start to be concluded in a matter of days," he told private Flash radio.

Key members of the IIF had met in Paris on Wednesday to decide how to proceed after the eurozone countries demanded lower interest rates on the new bonds.

The eurozone ministers have taken a tough stance because whatever debt relief Greece doesn't get from the investors will have to come from them and the International Monetary Fund, the country's bailout rescuers.

"To ensure debt sustainability for Greece, it is essential that a new program be supported by a combination of private sector involvement and official sector support," William Murray, an IMF spokesman, said late Wednesday.

Murray said the IMF has not asked the European Central Bank, which holds more than euro40 billion ($52 billion) in Greek government bonds, to play any specific role in relieving Greece's debt pile. The ECB, as a public sector holder of Greek debt, is protected from any writedown.

"The Fund has no view on the relative contribution of private sector involvement and official sector support in achieving" the target of cutting Greece's debt-to-GDP ratio to 120 percent, Murray said.

Source: http://us.rd.yahoo.com/dailynews/rss/eurobiz/*http%3A//news.yahoo.com/s/ap/20120126/ap_on_bi_ge/eu_greece_financial_crisis

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New Google Earth Release Eliminates 'Patchwork Quilt' Effects

Google Earth 6.2

Google released Google Earth 6.2 on Thursday, an update that eliminates the "patchwork quilt" effect from previous efforts.

Users can download the new update from Google, beginning today. The new update also adds the ability to share a screenshot on Google+, plus search layers, where users can perform local searches and get directions, much like they can on Google Maps.

The alterations to the imagery have been made on both the mobile and desktop versions of Google Earth, although Google said that Google 6.2 includes the best representation of the new feature.

The most significant change, of course, is Google's blending of its global imagery. Google Earth pulls in images from various sources, at variosu resolutions, so that major metropolitan areas and other points of interest are often recorded in higher resolutions than an isolated island in the Pacific Ocean.

A Google spokeswoman said that the company has streamlined the way in which those images are shown as a user "falls" or zooms in toward the planet.

"We are always working on making Google Earth imagery as seamless as possible," the Google spokeswoman said in an email. "These recent changes will make the map more beautiful by showing a single source of data at high altitudes, significantly reducing patchiness from orbit. You may notice as you zoom in that there will be shifts in imagery as data from different sources transitions in but we aim to minimize this effect through special processing."

Search functionality now features autocomplete, as well as a searh layer that will reveal all search results, and not just the top ten or so. The new release also adds biking, transit and walking directions, Google said.

For more from Mark, follow him on Twitter @MarkHachman.

For the top stories in tech, follow us on Twitter at @PCMag.

Source: http://feeds.ziffdavis.com/~r/ziffdavis/pcmag/breakingnews/~3/2D0wU-hCQ4Y/0,2817,2399441,00.asp

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Bernanke has "finger on trigger" for new bond buys (Reuters)

CHICAGO/NEW YORK (Reuters) ? The Federal Reserve has moved closer to embarking on a new round of its controversial money-pumping after the central bank and its chairman Ben Bernanke highlighted a grim outlook for the U.S. economy.

Bernanke on Wednesday opened the door a bit wider for the Fed to return to buying securities in the months ahead to buttress a weak recovery and keep inflation from slipping too far below its newly adopted 2-percent target.

"It sounds like the finger is on the trigger," said Thomas Simons, a money market economist at Jefferies & Co.

The Fed's announcement that it was unlikely to raise interest rates until at least late 2014, more than a year beyond its previous guidance, immediately pushed down Treasury bond yields and Bernanke's comments to the media raised expectations of a further round of so-called quantitative easing, or QE3.

It remains to be seen if the potential political backlash proves too daunting.

The prospect of the Fed pumping yet more money into the U.S. economy was seized upon by Republican hopeful Newt Gingrich to slam President Barack Obama's record. That highlighted the political pitfalls for the Fed in an election year.

Barring an unexpected pick-up in inflation or the U.S. economy suddenly kicking into a higher gear, Bernanke said it was logical that the Fed should look at ways to do more to help.

"The framework makes very clear that we need to be thinking about ways to provide further stimulus if we don't get improvement in the pace of recovery and a normalization of inflation," he told a quarterly news conference.

"Probably the main take-away from the press conference is the sense conveyed by Bernanke that it would not take much of a disappointment in growth or inflation to get the Fed to start another round of QE," said Michael Feroli, chief U.S. economist at J.P. Morgan.

"In fact, from his answers it's not even clear any disappointment would be necessary to see more QE," Feroli wrote in a note, adding he was not forecasting another round of asset purchases even if the bar for action was low.

The Fed in late 2008 slashed interest rates to near zero and has since bought $2.3 trillion in long-term securities in an unprecedented drive to spur growth and revive the economy after the worst recession in decades.

Yet the recovery has been slow and the outlook issued by the Fed on Wednesday was bleak.

With core inflation now at 1.7 percent and Fed officials forecasting unemployment to stay above 8 percent this year, many analysts took Bernanke's comments to mean QE3 is all but inevitable.

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Economic, rate projections http://link.reuters.com/zud36s

News conference after FOMC: http://link.reuters.com/xud36s

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MORTGAGES

The Fed has trained its sights on the stalled housing market in recent months, so any move to QE3 is most widely expected to involve buying mortgage securities to help bring down further already record-low mortgage interest rates.

Some economists said Bernanke may wait until the end in June of the Fed's "Operation Twist", which involves selling short-term bonds and buying longer-term ones in its $2.9 trillion portfolio to push down long-term interest rates further.

Bernanke may also want to wait until the market has absorbed his sweeping changes in communications policy which included the Fed adopting an explicit inflation target and releasing the interest rate projections of its policymakers for the first time on Wednesday.

Buying more mortgage-backed securities would drive down longer-term rates on mortgages with a view to countering what remains a drag on a U.S. economy still struggling to emerge from the worst recession in generations.

"I think it could happen any time now, based on the language that we saw today," said Eric Stein, a portfolio manager at Eaton Vance in Boston.

"I would think the first thing would be squarely focused on purchasing mortgage-backed securities, partially because Treasury yields are already so low, and housing is one of the major issues."

POLITICAL PITFALLS

The blowback from a heavy round of MBS purchases could be just as fierce as that provoked by the Fed's second round of quantitative easing which was announced in November 2010.

QE2, which targeted Treasuries, attracted sharp criticism from Republicans who warned it could fuel inflation and crimp the Fed's ability to tighten policy eventually, and who accused Bernanke of going beyond the central bank's mandate.

"People are now expecting more QE, and that would be in mortgages," said John Canally, investment strategist and economist at LPL Financial in Boston. "I think economically they (the Fed) would want to do that, but I don't know if politically they can withstand the forces against it."

Republican presidential candidates have repeatedly criticized the Fed and Bernanke on the campaign trail. Asked about the Fed's latest statement, Gingrich said it was "a sign of the failure of the entire Obama program" that Bernanke is bracing for such weak economic growth that he will have to keep rates low for so much longer.

At the same time the Fed is "putting in future inflation expectations," Gingrich told reporters in Florida on Wednesday. "It's more of Bernanke laying down a very bad future."

Foreign countries slammed the Fed's previous bond-buying programs, saying they artificially weakened the U.S. dollar and hurt their exporters. Brazil's finance minister talked of a "currency war."

Some economists say the political pressure on the Fed may prove too heavy.

"A third round of QE is still beyond them - or maybe the chairman simply doesn't have the stomach for the congressional mauling that further asset purchases would have precipitated....," said Ian Shepherdson, chief U.S. economist at High Frequency Economics.

Nonetheless, many others expect that the Fed will act again.

Economists at 12 of 18 primary dealers, the large financial institutions that do business directly with the Fed, believe the central bank will undertake further quantitative easing, according to a Reuters poll after Bernanke's news conference.

Some top investors have placed their bets, too.

Bill Gross, who runs the world's largest bond fund, has ramped up purchases of mortgage-backed securities which at the end of November accounted for 43 percent of his holdings. The self-styled "bond king" said last month that any QE3 would likely be focused on the housing sector.

Keith Wirtz, chief investment officer at Fifth Third Asset Management, with $18 billion in assets, said the Fed had gone "all in" with its promise to keep rates low through late 2014, and predicted that any rise in long-term borrowing costs would push the Fed to buy more bonds.

"Brace for QE3 if rates start to move higher on the long end," he said.

(Reporting by Ann Saphir and Jonathan Spicer; Additional reporting by Jennifer Ablan, Sam Youngman, Rodrigo Campos and Karen Brettell; Editing by Kim Coghill)

Source: http://us.rd.yahoo.com/dailynews/rss/economy/*http%3A//news.yahoo.com/s/nm/20120126/bs_nm/us_usa_fed

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Okla. hospital must pay $1M to Garth Brooks (AP)

CLAREMORE, Okla. ? An Oklahoma hospital in Garth Brooks' hometown must pay $1 million to the country singer because it failed to build a women's health center in honor of his late mother, jurors ruled Tuesday evening.

Jurors ruled that the hospital must return a $500,000 donation to Brooks plus pay him $500,000 in punitive damages in Brooks' breach-of-contract lawsuit against IntegrisCanadian Valley Regional Hospital in Yukon. Brooks said he thought he'd reached a deal in 2005 with the hospital's president, James Moore, but sued after learning the hospital wanted to use the money for other construction projects.

The hospital argued that Brooks gave it unrestricted access to the $500,000 donation and only later asked that it build a women's center and name it after his mother, Colleen Brooks, who died of cancer in 1999.

"Obviously we are disappointed, particularly with the jury's decision to award damages above and beyond the $500,000," Integris spokesman Hardy Watkins said. "We're just glad to see the case come to a resolution."

Brooks called the jurors "heroes" and said he felt vindicated by their verdict.

"I no longer feel like I'm crazy," he said.

Jury member Beverly Lacy said she voted in favor of Brooks because she thought the hospital went back on its word. As far as the punitive damages, she said: "We wanted to show them not to do that anymore to anyone else."

During the trial, Brooks testified that he thought he had a solid agreement with Moore. Brooks said the hospital president initially suggested putting his mother's name on an intensive care unit, and when Brooks said that wouldn't fit her image, Moore suggested a women's center.

"I jumped all over it," Brooks told jurors in tearful testimony. "It's my mom. My mom was pregnant as a teenager. She had a rough start. She wanted to help every kid out there."

His attorney told the jury during closing arguments that Brooks kept his end of the agreement.

"This case is about promises: promises made and promises broken," lawyer John Hickey told jurors shortly before they started deliberating. "Mr. Brooks kept his promise. Integris never intended to keep their promise and never built a new women's center."

But hospital attorney Terry Thomas said Brooks' gift initially came in anonymously and unrestricted in 2005. He also noted that Brooks couldn't remember key details of negotiations with the hospital's president ? including what he'd been promised ? when questioned during a deposition after filing his lawsuit in 2009.

"At most, it was a misunderstanding between these two," Thomas told jurors during his closing argument. "Am I calling Mr. Brooks a liar? Absolutely not. It's perfectly understandable that he does not remember these events."

The jury began deliberating Tuesday afternoon in Rogers County District Court, and the judge told jurors she wanted them to work as late as midnight to come to a decision.

Before the verdict was read, Brooks said the day had been emotional. The country music star said he was simply trying to honor his mother.

"This little pistol, she deserves nothing but good," Brooks said.

Source: http://us.rd.yahoo.com/dailynews/rss/topstories/*http%3A//news.yahoo.com/s/ap/20120125/ap_on_en_mu/us_people_garth_brooks

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McDonald's shares off on profit concerns (Reuters)

(Reuters) ? McDonald's Corp (MCD.N) reported stronger-than-expected December sales, but its shares fell on investor concerns that quarterly profit may have beat expectations only because of income that was not related to its operations.

Chief Financial Officer Pete Bensen said investors remain cautious about consumer spending. He added that as a percentage of sales, margins declined 30 basis points to 18.7 percent during the fourth quarter as higher costs for food and other items offset sales strength.

He also said that ongoing austerity measures in Europe have not hurt sales there and that "we're really seeing no change in customer behavior."

Shares of the world's biggest hamburger chain were down 1.4 percent to $99.48 in morning trading on Tuesday.

McDonald's reported fourth-quarter profit of $1.38 billion, or $1.33 per share, up from $1.24 billion, or $1.16 a share, a year earlier. Analysts on average expected $1.30 a share, according to Thomson Reuters I/B/E/S.

Edward Jones analyst Jack Russo said results from the latest quarter were helped by 3 cents per share of non-operating income.

"So it really it appears they met consensus," he said.

Revenue rose 10 percent to $6.82 billion, edging above the average analyst estimate of $6.81 billion.

Sales at stores open at least a year rose 9.6 percent in December, with a 9.8 percent increase in the United States and a 10.8 percent rise in its top revenue market of Europe.

Analysts on average forecast a 5.9 percent increase overall, with the a 5.4 percent increase in the United States and a 6.4 percent increase in Europe, according to Thomson Reuters I/B/E/S.

The results, which were helped by new menu items, restaurant renovations and effective marketing, defied a global economic slowdown, said Rikky Shoker, co-manager of the Credo Best Ideas Portfolio at Credo Group Ltd in London.

"This shows that McDonald's is a truly unique business and able to grow sales regardless of economic conditions," Shoker said.

McDonald's and its franchisees have been pouring money into their restaurants at a time when smaller and financially strapped chains are slashing costs.

The company also has broadened its appeal beyond the young men who account for the biggest share of sales at most other fast-food chains by adding low-cost Dollar Menu items and introducing high-margin beverages such as coffee and fruit smoothies.

Menu standouts during the quarter included bagel sandwiches in France and Big Mac's and chicken products in the United States, the company said.

(Reporting by Brad Dorfman in Chicago, editing by Dave Zimmerman)

Source: http://us.rd.yahoo.com/dailynews/rss/business/*http%3A//news.yahoo.com/s/nm/20120124/bs_nm/us_mcdonalds

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Can a lifetime of sudoku and crosswords help fight Alzheimer?s? (Yahoo! News)

A new UC Berkley study shows that reading, writing, and playing games keeps the brain free of Alzheimer's plaq??

All that time you've?spent reading books and?solving Rubik's cubes may have far more lasting benefits than previously thought. A?new University of California, Berkley study, published today, shows that a lifetime of activities that require high levels of brain function helps to fight the formation of the beta-amyloid proteins associated with Alzheimer's disease.

The study took a look at the brains of adults aged 60 or over, none of whom had?symptoms of Alzheimer's disease. Those who had a lengthy history of stimulating their brains with activities such as reading, writing, and solving puzzles were found to have the lowest levels of the beta-amyloid proteins in their brains.

An important factor in the study was the length of time which participants had been stimulating their brains. Those who only started increasing their brain activity in their senior years were found to more plaque than those who had high brain activity their whole lives. This suggests that a lifetime of brain-intensive activity may be useful in fighting off the?memory-destroying Alzheimer's plaques.

Once the symptoms of Alzheimer's begin to manifest, a lot of permanent and irreversible damage has already been done to the brain. This study shows the importance of a lifetime of mental stimulation in fighting Alzheimer's, as opposed to simply increasing brain activity as a senior.

(Source)

This article was written by Fox Van Allen and originally appeared on Tecca

More from Tecca:

Source: http://us.rd.yahoo.com/dailynews/rss/techblog/*http%3A//news.yahoo.com/s/yblog_technews/20120124/tc_yblog_technews/can-a-lifetime-of-sudoku-and-crosswords-help-fight-alzheimers

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AP IMPACT: Meth fills hospitals with burn patients (AP)

ST. LOUIS ? A crude new method of making methamphetamine poses a risk even to Americans who never get anywhere near the drug: It is filling hospitals with thousands of uninsured burn patients requiring millions of dollars in advanced treatment ? a burden so costly that it's contributing to the closure of some burn units.

So-called shake-and-bake meth is produced by combining raw, unstable ingredients in a 2-liter soda bottle. But if the person mixing the noxious brew makes the slightest error, such as removing the cap too soon or accidentally perforating the plastic, the concoction can explode, searing flesh and causing permanent disfigurement, blindness or even death.

An Associated Press survey of key hospitals in the nation's most active meth states showed that up to a third of patients in some burn units were hurt while making meth, and most were uninsured. The average treatment costs $6,000 per day. And the average meth patient's hospital stay costs $130,000 ? 60 percent more than other burn patients, according to a study by doctors at a burn center in Kalamazoo, Mich.

The influx of patients is overwhelming hospitals and becoming a major factor in the closure of some burn wards. At least seven burn units across the nation have shut down over the past six years, partly due to consolidation but also because of the cost of treating uninsured patients, many of whom are connected to methamphetamine.

Burn experts agree the annual cost to taxpayers is well into the tens if not hundreds of millions of dollars, although it is impossible to determine a more accurate number because so many meth users lie about the cause of their burns.

Larger meth labs have been bursting into flame for years, usually in basements, backyard sheds or other private spaces. But those were fires that people could usually escape. Using the shake-and-bake method, drugmakers typically hold the flammable concoction up close, causing burns from the waist to the face.

"You're holding a flame-thrower in your hands," said Jason Grellner of the Franklin County, Mo., Sheriff's Department.

Also known as the "one-pot" approach, the method is popular because it uses less pseudoephedrine ? a common component in some cold and allergy pills. It also yields meth in minutes rather than hours, and it's cheaper and easier to conceal. Meth cooks can carry all the ingredients in a backpack and mix them in a bathroom stall or the seat of a car.

The improvised system first emerged several years ago, partly in response to attempts by many states to limit or forbid over-the-counter access to pseudoephedrine. Since then, the shake-and-bake recipe has spread to become the method of choice.

By 2010, about 80 percent of labs busted by the federal Drug Enforcement Administration were using shake-and-bake recipes, said Pat Johnakin, a DEA agent specializing in meth.

So instead of a large lab that supplies many users, there are now more people making meth for their personal use. The consequences are showing up in emergency rooms and burn wards.

"From what we see on the medical side, that's the primary reason the numbers seem to be going up: greater numbers of producers making smaller batches," said Dr. Michael Smock, director of the burn unit at Mercy Hospital St. Louis.

It's impossible to know precisely how many people are burned while making shake-and-bake meth. Some avoid medical treatment, and no one keeps exact track of those who go to the hospital. But many burn centers in the nation's most active meth-producing states report sharp spikes in the number of patients linked to meth. And experts say the trend goes well beyond those facilities.

The director of the burn center at Vanderbilt University in Tennessee, the state that led the nation in meth lab seizures in 2010, said meth injuries are doubly damaging because patients often suffer thermal burn from the explosion, as well as chemical burns. And the medical challenge is compounded by patients' addictions.

"You're not judgmental in this kind of work, but you see it day after day," said Vanderbilt's Dr. Jeffrey Guy. "We've had patients say, `I'm going out for a smoke,' and they come back all jacked up. It's clear they went out and did meth again."

Few people burned by meth will admit it.

"We get a lot of people who have strange stories," said Dr. David Greenhalgh, past president of the American Burn Association and director of the burn center at the University of California, Davis. "They'll say they were working on the carburetor at 2 or 3 in the morning and things blew up. So we don't know for sure, but 25 to 35 percent of our patients are meth-positive when we check them."

Guy cited a similar percentage at Vanderbilt, which operates the largest burn unit in Tennessee. He said the lies can come with a big price because the chemicals used in meth-making are often as dangerous as the burns themselves.

He recalled the case of a woman who arrived with facial burns that she said were caused by a toaster. As a result, she didn't tell doctors that meth-making chemicals got into her eyes, delaying treatment.

"Now she's probably going to be blind because she wasn't honest about it," Guy said.

In Indiana, about three-quarters of meth busts now involve shake-and-bake. And injuries are rising sharply, mostly because of burns, said Niki Crawford of the Indiana State Police Meth Suppression Team.

Indiana had 89 meth-related injuries during the 10-year period ending in 2009. The state has had 70 in the last 23 months, mostly from shake-and-bake labs, Crawford said.

What's more, meth-related burns often sear some of the body's most sensitive areas ? the face and hands.

"I don't think a lot of these patients will be able to re-enter society, said Dr. Lucy Wibbenmeyer of the burn center at the University of Iowa. "They'll need rehab therapy, occupational therapy, which is very expensive."

Researchers at the University of Iowa found that people burned while making meth typically have longer hospital stays and more expensive bills than other burn patients ? bills that are frequently absorbed by the hospital since a vast majority of the meth-makers lack insurance.

Medicaid provides reimbursement for many patients lacking private insurance, but experts say it amounts to pennies on the dollar.

Doctors at Bronson Methodist Hospital in Kalamazoo, Mich., performed a five-year study of meth patients in the early 2000s, then a follow-up study in 2009-2010. Their investigation concurred with the Iowa findings. The Kalamazoo study also found that meth burn victims were more likely to suffer damage to the lungs and windpipe, spent more time on ventilators and needed surgery more often.

That report also found that only about 10 percent of meth patients had private insurance coverage, compared with 59 percent of other patients. And in many cases, their injuries leave them unable to work.

Source: http://us.rd.yahoo.com/dailynews/rss/topstories/*http%3A//news.yahoo.com/s/ap/20120123/ap_on_re_us/us_meth_severe_burns

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AP IMPACT: Meth fills hospitals with burn patients

This photo provided Jan. 10, 2012, by the Franklin County Sheriff?s Department shows firefighters battling a blaze from a shake-and-bake meth lab explosion Jan. 29, 2010, at a house in Union, Mo. The crude new method of making methamphetamine, by combining raw and unstable ingredients in a 2-liter soda bottle, poses a risk even to Americans who never get anywhere near the drug: It is filling hospitals with thousands of uninsured burn patients requiring millions of dollars in advanced treatment _ a burden so costly that it?s contributing to the closure of some burn units. (AP Photo/Franklin County Sheriff?s Department )

This photo provided Jan. 10, 2012, by the Franklin County Sheriff?s Department shows firefighters battling a blaze from a shake-and-bake meth lab explosion Jan. 29, 2010, at a house in Union, Mo. The crude new method of making methamphetamine, by combining raw and unstable ingredients in a 2-liter soda bottle, poses a risk even to Americans who never get anywhere near the drug: It is filling hospitals with thousands of uninsured burn patients requiring millions of dollars in advanced treatment _ a burden so costly that it?s contributing to the closure of some burn units. (AP Photo/Franklin County Sheriff?s Department )

This photo provided Jan. 10, 2012, by the Franklin County Sheriff?s Department shows shake-and-bake meth ingredients found at house that burned from a meth lab explosion Jan. 29, 2010, in Union, Mo. The crude new method of making methamphetamine, by combining raw and unstable ingredients in a 2-liter soda bottle, poses a risk even to Americans who never get anywhere near the drug: It is filling hospitals with thousands of uninsured burn patients requiring millions of dollars in advanced treatment _ a burden so costly that it?s contributing to the closure of some burn units. (AP Photo/Franklin County Sheriff?s Department )

This dashboard police video photo provided Jan. 17, 2012, by the Tennessee Methamphetamine Task Force shows what authorities say is a mobile shake-and-bake meth lab vehicle burning in August, 2011, in Clarksville, Tenn. The crude new method of making methamphetamine, by combining raw and unstable ingredients in a 2-liter soda bottle, poses a risk even to Americans who never get anywhere near the drug: It is filling hospitals with thousands of uninsured burn patients requiring millions of dollars in advanced treatment _ a burden so costly that it?s contributing to the closure of some burn units. (AP Photo/Tennessee Methamphetamine Task Force)

This photo provided Jan. 19, 2012, by the Tennessee Methamphetamine Task Force shows shows the interior of a home in Clarksville, Tenn., damaged by a shake-and-bake meth lab explosion in December, 2011. The crude new method of making methamphetamine, by combining raw and unstable ingredients in a 2-liter soda bottle, poses a risk even to Americans who never get anywhere near the drug: It is filling hospitals with thousands of uninsured burn patients requiring millions of dollars in advanced treatment _ a burden so costly that it?s contributing to the closure of some burn units. (AP Photo/Tennessee Methamphetamine Task Force, Jesse Reynolds)

This photo provided Jan. 17, 2012, by the Tennessee Methamphetamine Task Force shows the aftermath what authorities say is a mobile shake-and-bake meth lab vehicle that burned in August, 2011, in Clarksville, Tenn. The crude new method of making methamphetamine, by combining raw and unstable ingredients in a 2-liter soda bottle, poses a risk even to Americans who never get anywhere near the drug: It is filling hospitals with thousands of uninsured burn patients requiring millions of dollars in advanced treatment _ a burden so costly that it?s contributing to the closure of some burn units. (AP Photo/Tennessee Methamphetamine Task Force)

(AP) ? A crude new method of making methamphetamine poses a risk even to Americans who never get anywhere near the drug: It is filling hospitals with thousands of uninsured burn patients requiring millions of dollars in advanced treatment ? a burden so costly that it's contributing to the closure of some burn units.

So-called shake-and-bake meth is produced by combining raw, unstable ingredients in a 2-liter soda bottle. But if the person mixing the noxious brew makes the slightest error, such as removing the cap too soon or accidentally perforating the plastic, the concoction can explode, searing flesh and causing permanent disfigurement, blindness or even death.

An Associated Press survey of key hospitals in the nation's most active meth states showed that up to a third of patients in some burn units were hurt while making meth, and most were uninsured. The average treatment costs $6,000 per day. And the average meth patient's hospital stay costs $130,000 ? 60 percent more than other burn patients, according to a study by doctors at a burn center in Kalamazoo, Mich.

The influx of patients is overwhelming hospitals and becoming a major factor in the closure of some burn wards. At least seven burn units across the nation have shut down over the past six years, partly due to consolidation but also because of the cost of treating uninsured patients, many of whom are connected to methamphetamine.

Burn experts agree the annual cost to taxpayers is well into the tens if not hundreds of millions of dollars, although it is impossible to determine a more accurate number because so many meth users lie about the cause of their burns.

Larger meth labs have been bursting into flame for years, usually in basements, backyard sheds or other private spaces. But those were fires that people could usually escape. Using the shake-and-bake method, drugmakers typically hold the flammable concoction up close, causing burns from the waist to the face.

"You're holding a flame-thrower in your hands," said Jason Grellner of the Franklin County, Mo., Sheriff's Department.

Also known as the "one-pot" approach, the method is popular because it uses less pseudoephedrine ? a common component in some cold and allergy pills. It also yields meth in minutes rather than hours, and it's cheaper and easier to conceal. Meth cooks can carry all the ingredients in a backpack and mix them in a bathroom stall or the seat of a car.

The improvised system first emerged several years ago, partly in response to attempts by many states to limit or forbid over-the-counter access to pseudoephedrine. Since then, the shake-and-bake recipe has spread to become the method of choice.

By 2010, about 80 percent of labs busted by the federal Drug Enforcement Administration were using shake-and-bake recipes, said Pat Johnakin, a DEA agent specializing in meth.

So instead of a large lab that supplies many users, there are now more people making meth for their personal use. The consequences are showing up in emergency rooms and burn wards.

"From what we see on the medical side, that's the primary reason the numbers seem to be going up: greater numbers of producers making smaller batches," said Dr. Michael Smock, director of the burn unit at Mercy Hospital St. Louis.

It's impossible to know precisely how many people are burned while making shake-and-bake meth. Some avoid medical treatment, and no one keeps exact track of those who go to the hospital. But many burn centers in the nation's most active meth-producing states report sharp spikes in the number of patients linked to meth. And experts say the trend goes well beyond those facilities, easily involving thousands of drug users.

The director of the burn center at Vanderbilt University in Tennessee, the state that led the nation in meth lab seizures in 2010, said meth injuries are doubly damaging because patients often suffer thermal burn from the explosion, as well as chemical burns. And the medical challenge is compounded by patients' addictions.

"You're not judgmental in this kind of work, but you see it day after day," said Vanderbilt's Dr. Jeffrey Guy. "We've had patients say, 'I'm going out for a smoke,' and they come back all jacked up. It's clear they went out and did meth again."

Few people burned by meth will admit it.

"We get a lot of people who have strange stories," said Dr. David Greenhalgh, past president of the American Burn Association and director of the burn center at the University of California, Davis. "They'll say they were working on the carburetor at 2 or 3 in the morning and things blew up. So we don't know for sure, but 25 to 35 percent of our patients are meth-positive when we check them."

Guy cited a similar percentage at Vanderbilt, which operates the largest burn unit in Tennessee. He said the lies can come with a big price because the chemicals used in meth-making are often as dangerous as the burns themselves.

He recalled the case of a woman who arrived with facial burns that she said were caused by a toaster. As a result, she didn't tell doctors that meth-making chemicals got into her eyes, delaying treatment.

"Now she's probably going to be blind because she wasn't honest about it," Guy said.

In Indiana, about three-quarters of meth busts now involve shake-and-bake. And injuries are rising sharply, mostly because of burns, said Niki Crawford of the Indiana State Police Meth Suppression Team.

Indiana had 89 meth-related injuries during the 10-year period ending in 2009. The state has had 70 in the last 23 months, mostly from shake-and-bake labs, Crawford said.

What's more, meth-related burns often sear some of the body's most sensitive areas ? the face and hands.

"I don't think a lot of these patients will be able to re-enter society, said Dr. Lucy Wibbenmeyer of the burn center at the University of Iowa. "They'll need rehab therapy, occupational therapy, which is very expensive."

Researchers at the University of Iowa found that people burned while making meth typically have longer hospital stays and more expensive bills than other burn patients ? bills that are frequently absorbed by the hospital since a vast majority of the meth-makers lack insurance.

Medicaid provides reimbursement for many patients lacking private insurance, but experts say it amounts to pennies on the dollar.

Doctors at Bronson Methodist Hospital in Kalamazoo, Mich., performed a five-year study of meth patients in the early 2000s, then a follow-up study in 2009-2010. Their investigation concurred with the Iowa findings. The Kalamazoo study also found that meth burn victims were more likely to suffer damage to the lungs and windpipe, spent more time on ventilators and needed surgery more often.

That report also found that only about 10 percent of meth patients had private insurance coverage, compared with 59 percent of other patients. And in many cases, their injuries leave them unable to work.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2012-01-23-Meth-Severe%20Burns/id-c0bd910f1f04435a8092acd8534b2a00

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Patterns of chromosome abnormality: The key to cancer?

Monday, January 23, 2012

A healthy genome is characterized by 23 pairs of chromosomes, and even a small change in this structure ? such as an extra copy of a single chromosome ? can lead to severe physical impairment. So it's no surprise that when it comes to cancer, chromosomal structure is frequently a contributing factor, says Prof. Ron Shamir of the Blavatnik School of Computer Science at Tel Aviv University.

Now Prof. Shamir and his former doctoral students Michal Ozery-Flato and Chaim Linhart, along with fellow researchers Prof. Shai Izraeli and Dr. Luba Trakhtenbrot from the Sheba Medical Center, have combined techniques from computer science and statistics to discover that many chromosomal pairs are lost or gained together across various cancer types. Moreover, the researchers discovered a new commonality of chromosomal aberrations among embryonic cancer types, such as kidney, skeleton, and liver cancers.

These findings, recently published in Genome Biology, could reveal more about the nature of cancer. As cancer develops, the genome becomes increasingly mutated ? and identifying the pattern of mutation can help us to understand the nature and the progression of many different kinds of cancer, says Prof. Shamir.

Looking at the big picture

As cancer progresses, the structure of chromosomes is rearranged, individual chromosomes are duplicated or lost, and the genome becomes abnormal. Some forms of cancer can even be diagnosed by identifying individual chromosomal aberrations, notes Prof. Shamir, pointing to the example of a specific type of leukemia that is caused by small piece of chromosome 9 being moved to chromosome 22.

When analyzing many different kinds of cancer, however, the researchers discovered that chromosomal aberrations among different cancers happen together in a noticeable and significant way. The researchers studied a collection of more than fifty thousand cancer karyotypes ? representations of chromosomal layouts in a single cell ? and charted them according to commonalities. The researchers were not only able to confirm different chromosomal aberrations that appeared in specific cancer types, but also for the first time identified a broader effect of pairs of chromosomes being lost or gained together across different cancer types.

It was also the first time that researchers saw a connection among solid kidney, skeleton, and liver cancers. While it was known that these cancers all develop in the embryo, they were previously analyzed independently. The TAU researchers have now confirmed that they share chromosomal characteristics and aberrations, much like various forms of leukemia or lymphomas.

Aberrations a driving force for cancer

Under normal circumstances, even a small change to a person's chromosomal structure can be devastating. For example, Down's syndrome is caused by a single extra copy of Chromosome 21. "But in cancer, there are many cases of extra or missing chromosomes. Yet cancer cells thrive more effectively than other cells," Prof. Shamir says.

Prof. Shamir hopes that future investigation into these chromosomal aberrations will give researchers more clues into why something that is so detrimental to our healthy development is so beneficial to this disease. Cancer is the result of sequences of events, he says, each causing the genome to become more mutated, mixed, and duplicated. Tracking these changes could aid our understanding of the driving forces of cancer's progress.

###

American Friends of Tel Aviv University: http://www.aftau.org

Thanks to American Friends of Tel Aviv University for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/116946/Patterns_of_chromosome_abnormality__The_key_to_cancer_

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Rosenthal: They believed, Alex Smith delivered

49ers quarterback is 2 victories away from ultimate football glory after nearly being left for dead

Image: Smith scores TDGetty Images

49ers quarterback Alex Smith runs in for a touchdown during his team's victory over the Saints in the divisional playoffs last Saturday.

updated 6:06 p.m. ET Jan. 20, 2012

Gregg Rosenthal

?We want Carr. We want Carr!?

It was the lowest moment of Alex Smith?s seven-year career in San Francisco, Oct. 12, 2010. The winless 49ers hosted the Eagles on Sunday Night Football, and the crowd was looking for blood.

After his fourth-quarter fumble, thunderous boos poured down on Smith. He was hearing it all game from the crowd, but this matched anything I?ve ever heard ? even in Philadelphia. The unmistakable chant that came with the booing was even more depressing.

?We want Carr. We want Carr!?

The home crowd wanted Smith benched in favor of backup quarterback David Carr. The fan base collectively waved the white flag. They were tired of their No. 1 overall pick bust and wanted to try another. It was only Week 5 of a rapidly devolving season.

Coach Mike Singletary tried to remove Smith from the game, but the quarterback barked back. He talked his way into staying in the contest. He wound up throwing for more than 300 yards with three touchdowns in a comeback attempt that fell just short, like so many other 49er games during Smith?s tenure.

The fans got their wish two weeks later when Carr replaced an injured Smith during a loss to the Panthers. Troy Smith wound up starting six games for the 2010 49ers. Alex Smith?s beleaguered run in San Francisco was all but over. If nothing else, that gave the fans something to smile about.

Between rare and extinct
David Carr tells us a lot about Alex Smith. Just like Smith, Carr was a No. 1 overall draft pick viewed as a franchise savior. Like Smith, Carr fell flat on his face.

Carr didn?t face the same injury struggles as Smith. Carr didn?t have two head coaches question his toughness. But after five years in Houston, Carr was beat up mentally and physically. When Carr hit free agency, he wanted to take a break.? He wanted out.

"I need to take a deep breath and be around a good environment and just start enjoying the game again,'' Carr said in 2007. ?I wanted to be on a team that was fun and exciting and whether I had a chance to play right away, it didn't matter to me.''

Smith had his chance to take a deep breath last offseason. His family wanted him to leave San Francisco, toasting to new beginnings after this season. Smith didn?t want to go anywhere.

That desire to finish what he started won over new 49ers coach Jim Harbaugh.

"I wanted to get to know him. I had never met him," Harbaugh said last week of his first meeting with Smith in January 2011. "I was just kind of looking in through the keyhole. But I guess the things that I wanted to know, if you boiled it down to one thing, was, did he want to start? Did he want be in the fire? Or did he want to wear the ball cap backward and backup somewhere??

Harbaugh was asking if Alex Smith wanted to be David Carr. (Or Vince Young. Or Matt Leinart. Or JaMarcus Russell.)

"I really felt that he had the competitive drive, the (desire) to prove himself, him wanting to do it here. That's the thing that probably intrigued me the most. That character of wanting to come back and do it here in San Francisco, which is pretty rare ? probably somewhere between rare and extinct. That's not just for football players. That's about anybody. ... And I thought we could really work with that character. To me that was special."

Smith?s seven fourth-quarter comeback victories this season are special. His league-leading interception percentage says a lot. But the most impressive part of Smith?s season is that he?s there at all. He survived.

The things Alex carries
Alex Smith carries his six seasons through the professional football meat grinder everywhere he goes. He carries the old playbooks; the losses; the chants; the manipulative coaches; the shoulder surgeries.

Smith has gone through this 14-3 season hesitant to look back. It?s as if he doesn?t want to jinx what?s happening.

Seven offensive coordinators
Smith?s first offensive coordinator was Mike McCarthy, who pushed the team to draft Smith over Aaron Rodgers with the No. 1 pick in 2005.

One touchdown, 11 interceptions by Smith later, McCarthy scored the Packers' head coaching job before his coaching stock sunk any further.

Norv Turner came next and guided Smith to a promising second season. Smith appeared to have turned a corner. It?s a reminder what good teaching can mean for a young quarterback.? Smith wouldn?t learn that lesson again until 2011.? Turner left after ?06 for the Chargers head coaching job.

Jim Hostler, Mike Martz, Jimmy Raye, and Mike Johnson followed Turner to disappointing results. Each man had a new idea of how an NFL offense should look and how Smith fit into their system. Some liked Smith more than others. Every spring meant a new playbook.

Smith?s seventh coordinator was the charm. Jim Harbaugh knows the quarterback position as well as any head coach, but he also brought in a terrific staff to help him. It?s one of the most underrated skills a head coach can have. Can he choose the right men to assist him?

Offensive coordinator Greg Roman and quarterbacks coach Geep Chryst have both done a fabulous job with Smith. It was Chryst who took over the play-calling late in the divisional round win over the Saints. Along with Harbaugh, the three men collaborate on one of the smartest offensive attacks in the league.

They create big-play opportunities without taking much risk. They accentuate what Smith does well and limit his weaknesses being exposed. They put Smith in position to succeed. That?s coaching.

2 misguided head coaches
Alex Smith?s rookie season was Mike Nolan?s rookie season as a head coach. Both men looked comfortable in their new role.

Nolan ran the 49ers through fear. He often seemed unnecessarily paranoid and played misguided mental games. When Smith?s shoulder was hurt in 2007, Nolan implied publicly that Smith wasn?t fighting through the injury. Nolan came out told the 49ers team behind closed doors that Smith was using his shoulder injury as an excuse for poor play. Smith fought back by speaking out.

?I felt it was trying to undermine me with my teammates,? Smith said back then.

Smith had shoulder surgery after the season.

The next 49ers head coach was a defensive-minded motivational speaker: Mike Singletary. Singletary said multiple times he didn?t think quarterback was the most important position on the field. He once called Smith ?meek.? After Singletary was fired, he was asked what he learned from the experience.

"You gotta have a quarterback," Singletary said.

These were the men in charge. They never believed in Smith.

Harbaugh saw something different in that first meeting with Smith. Most importantly, he saw a quietly improved player on film. Harbaugh?s effusive and immediate praise of Smith almost seemed comical. (He once said Smith had ?armadillo skin .?)

Smith, a free agent, publicly expressed doubt he?d return to San Francisco before Harbaugh started recruiting Smith with regular meetings. No one in San Francisco knew what to make of it. Why would the new hot shot coach stick out his neck for Smith?

?I?ve been studying Alex Smith and watching him and I believe that Alex Smith can be a winning quarterback in the National Football League,? Harbaugh said. ?Very accurate passer. Very athletic. And a guy that has played and been durable.?

This was January 2011. Harbaugh embraced the quarterback no one wanted. The message hasn?t changed since. The love affair has only grown.

The teammates
Smith was benched for the following quarterbacks during his 49ers career: Tim Rattay, Ken Dorsey, Trent Dilfer, Shaun Hill, J.T. O?Sullivan, and Troy Smith.

Guys like Carr and Cody Pickett replaced Smith when he was hurt. Only Hill went on to a modicum of success after leaving San Francisco.

The following wide receivers have started games during Smith?s tenure in San Francisco: ?Brandon Lloyd, Arnaz Battle, Johnnie Morton, Kevin McAddley, Antonio Bryant, Bryan Gilmore, Darrell Jackson, Ashley Lelie, Isaac Bruce, Bryant Johnson, Jason Hill, Josh Morgan, Michael Crabtree, Braylon Edwards, Ted Ginn, Kyle Williams, and Brett Swain.

Change was the only constant in San Francisco?s passing attack. Personnel objectives changed annually with the rotating offensive systems. Players past their prime were brought in like Morton, Jackson, and Bruce. Failed draft picks from other teams were given a second chance like Lelie, Johnson, Edwards, and Ginn. Very little stuck.

Even today, San Francisco?s wide receivers struggle to beat man coverage. It?s a concern this week going against a Giants defense that can get pressure with their front four and played great man coverage last week in Green Bay.

Harbaugh knows all this. He built an offense around the run game, his tight ends, and carefully orchestrated ?shot plays? the wideouts wouldn?t have to win consistently on the outside. He relied on Smith?s accuracy and decision making.

When Harbaugh has asked Smith and his receivers to carry the offense ? against the Giants and Saints ? they have found a way.

Bad habits
Smith deserves his share of blame for struggling until Harbaugh came along. He doesn?t have the big arm you?d expect of a top pick. He?s smart but has struggled to translate those smarts into instinct. He was deliberate making decisions.

Going back through five years of my game notes, the same word came up repeatedly describing Smith: tentative. He took the safe play. He didn?t have enough confidence in himself, his receivers, or perhaps his offense to make the difficult throw.

That slowly started to change this year. The 49ers are not an aggressive passing team, but Smith has played his best with the game on the line.

Back-to-back fourth-quarter comeback wins in Cincinnati and Philadelphia kick-started things. Smith threw a fourth-and-goal game-winner to Delanie Walker in Detroit. An insane 41-yard toss to Michael Crabtree set up the game-winning field goal in Seattle.

In most of those games, the 49ers still coached around Smith. Their wins were more about the defense, running game and short, safe passes. Last Saturday against the Saints, the 49ers coaching staff gave the keys to Smith.

"The winning touchdown to Vernon Davis ... and I'm taking nothing away from Vernon Davis's catch ... the throw made that play, not the catch," NFL Films guru Greg Cosell said on KNBR this week. ?He threw that ball before Davis even got past the underneath linebacker.?

The 49ers could have played for the tie, but they went for the win because of the confidence they had in Smith. It was the type of instinctive, anticipatory, gutsy throw we haven?t seen from Smith. Smith is starting to mix in aggression with his smarts. That could be a championship combination.

The other side
Alex Smith is Mark Sanchez if Sanchez went through another three years like the one he just had.

Smith took all the abuse we could hurl at him and emerged on the other side. He will never be Joe Montana, but that?s not the point. He?s here. He is one game away from playing in the Super Bowl. After what Smith has been through, he deserves to enjoy this moment.

Perhaps Smith will take a deep breath during the national anthem on Sunday and allow himself a peak at the opposing sideline. Giants backup quarterback David Carr will be standing there, representing the road more traveled.

When the anthem ends, Carr will reach to put on his backward hat. Smith will grab his helmet.


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Belichick the greatest coach ever?

CSN: We revere Noll, Shula, Lombardi, Walsh and Brown, but Bill Belichick could wind up the greatest coach ever ? and it's a lot harder now.

Source: http://nbcsports.msnbc.com/id/46067758/ns/sports-nfl/

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