Migratory gene expression signature predicts poor patient outcome: Are cancer stem cells to blame?

Abstract (provisional)

Breast cancer metastasis accounts for the majority of deaths from this disease. In this journal, Patsialou, et al., utilize a novel in vivo invasion assay to capture migrating breast cancer cells and demonstrate that the gene expression signature of these cells predicts breast cancer metastasis in a large patient cohort. Furthermore, specific genes identified play a functional role in invasion of MDA-MB-231 breast cancer cells as well as in patient derived breast tumors. These genes regulate pathways known to be induced in invasion and metastases as well as playing an important role in the regulation of cancer stem cells.

The complete article is available as a provisional PDF. The fully formatted PDF and HTML versions are in production.

Source: http://breast-cancer-research.com/content/14/6/114

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